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강경아 ( Kang Kyoung-Ah ) - 경희대학교 간호학과
한상숙 ( Han Sang-Sook ) - 경희대학교 간호과학대학
이무형 ( Lee Mu-Hyoung ) - 경희대학교 의과대학 고황의학연구소
김윤정 ( Kim Youn-Jung ) - 경희대학교 간호과학대학
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Abstract
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Purpose: To screen candidate oriental herb material for antimelanogenics.
Methods: Oriental herbs (n=100) were screened for mushroom tyrosinase inhibitory activity in vitro using the HM3KO human melanin cell line cultured in DMEM supplemented with 10% fetal bovine serum. Cytotoxicity was assessed by a cell viability assay involving 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Trypan Blue exclusion, and cell enumeration.
Results: Tyrosinase inhibitory effects on 100 oriental herbs was evident. Of these, 11 herbs inhibited tyrosinase activity by 40% without being cytotoxic to HM3KO cells. Three herb varieties significantly decreased melanin synthesis in HM3KO cells.
Conclusions: Oriental herb can have antimelanogenic effects indicating their potential for functional therapeutic use in dermatological whitening.
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KeyWords
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멜라닌, 타이로시네이즈, 미백, 한약재
Melanin, Tyrosinase, Whitening, Herb
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원문 및 링크아웃 정보
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등재저널 정보
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